Relevant re-connections occur in the brain of the visual impaired: the brain does not go ‘unused’. It gets devoted to deal other sensory modalities. For example, the primary visual cortex gets activated during Braille reading. In a recent preliminary study, presented at the IEEE-EMBC 2022, we have seen that the visual cortex of rats with retinal degeneration activates faster than in the sighted controls following auditory stimulation. These early results suggest that compensatory neural rewiring takes place in murine models too. But, can this re-connections promote or deter visual neuro-rehabilitation? Our research continues…